The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model.

ABSTRACT

C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.