Molecular dynamics simulation study reveals potential substrate entry path into Î³-secretase/presenilin-1.

Kong, Ren; Chang, Shan; Xia, Weiming; Wong, Stephen T C

Kong, Ren; Chang, Shan; Xia, Weiming; Wong, Stephen T C.

Afiliação

Kong R; Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX, USA; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, China.
Chang S; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, China.
Xia W; Department of Veterans Affairs, Medical Research & Development Service and Geriatric Research, Education and Clinical Center, Bedford, MA, USA.
Wong ST; Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX, USA. Electronic address: stwong@houstonmethodist.org.

J Struct Biol ; 191(2): 120-9, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26142917

Assuntos

Secretases da Proteína Precursora do Amiloide/química; Simulação de Dinâmica Molecular; Presenilina-1/química; Humanos; Modelos Moleculares; Análise de Componente Principal; Estrutura Terciária de Proteína; Relação Estrutura-Atividade

Palavras-chave

Membrane protein; Molecular dynamics simulation; Presenilin-1; Î³-Secretase

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Secretases da Proteína Precursora do Amiloide / Presenilina-1 / Simulação de Dinâmica Molecular Limite: Humans Idioma: En Revista: J Struct Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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