The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats.

Moaddel, Ruin; Sanghvi, Mitesh; Dossou, Katina Sourou Sylvestre; Ramamoorthy, Anuradha; Green, Carol; Bupp, James; Swezey, Robert; O'Loughlin, Kathleen; Wainer, Irving W

Moaddel, Ruin; Sanghvi, Mitesh; Dossou, Katina Sourou Sylvestre; Ramamoorthy, Anuradha; Green, Carol; Bupp, James; Swezey, Robert; O'Loughlin, Kathleen; Wainer, Irving W.

Afiliação

Moaddel R; Laboratory of Clinical Investigation, Division of Intramural Research Programs, National Institute on Aging, National Institutes of Health Baltimore, Maryland, 21224.
Sanghvi M; Laboratory of Clinical Investigation, Division of Intramural Research Programs, National Institute on Aging, National Institutes of Health Baltimore, Maryland, 21224.
Dossou KS; Laboratory of Clinical Investigation, Division of Intramural Research Programs, National Institute on Aging, National Institutes of Health Baltimore, Maryland, 21224.
Ramamoorthy A; Laboratory of Clinical Investigation, Division of Intramural Research Programs, National Institute on Aging, National Institutes of Health Baltimore, Maryland, 21224.
Green C; Biosciences, SRI International Menlo Park, California.
Bupp J; Biosciences, SRI International Menlo Park, California.
Swezey R; Biosciences, SRI International Menlo Park, California.
O'Loughlin K; Biosciences, SRI International Menlo Park, California.
Wainer IW; Laboratory of Clinical Investigation, Division of Intramural Research Programs, National Institute on Aging, National Institutes of Health Baltimore, Maryland, 21224.

Pharmacol Res Perspect ; 3(4): e00157, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26171236

Palavras-chave

Antidepressant; bioavailability of (2S,6S)-HNK; brain concentrations; plasma half-life and distribution of (2S,6S)-HNK

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Pharmacol Res Perspect Ano de publicação: 2015 Tipo de documento: Article