Pathophysiological Study of Sensitive Skin.
Acta Derm Venereol
; 96(3): 314-8, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26337000
ABSTRACT
Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation of peripheral innervation, the pathophysiogeny of sensitive skin remains unknown. We systematically analysed cutaneous biopsies from 50 healthy women with non-sensitive or sensitive skin and demonstrated that the intraepidermal nerve fibre density, especially that of peptidergic C-fibres, was lower in the sensitive skin group. These fibres are involved in pain, itching and temperature perception, and their degeneration may promote allodynia and similar symptoms. These results suggest that the pathophysiology of skin sensitivity resembles that of neuropathic pruritus within the context of small fibre neuropathy, and that environmental factors may alter skin innervation.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Dor
/
Prurido
/
Pele
/
Fibras Nervosas Amielínicas
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Acta Derm Venereol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França