Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques.
Biomed Res Int
; 2015: 769806, 2015.
Article
em En
| MEDLINE
| ID: mdl-26351638
ABSTRACT
OBJECTIVES:
This study analyzed the long-term hearing loss after treatment of primary nasopharyngeal carcinoma to elucidate its causal factors.METHODS:
Ninety-two nasopharyngeal carcinoma patients were treated with radiotherapy or chemoradiotherapy. Pure tone audiometry was performed before the therapy and annually up to 9 years after completing treatment. The hearing thresholds were corrected for age-related deterioration and compared to the results without adjusting for age.RESULTS:
The mean air and bone conduction threshold with and without correction for age-related deterioration differed significantly 2-9 years after completing radiotherapy (p < 0.05). The audiometry results with age correction showed a flattened configuration compared to the results without age correction. The total radiation dose and radiation modality showed a causal relationship with a greater incidence of hearing loss after therapy (p < 0.05). There was more deterioration in the air and bone hearing thresholds with conformal radiotherapy than intensity-modulated radiotherapy (p < 0.001). A radiation dose >72 cGy resulted in more severe hearing loss than <72 cGy (p < 0.05).CONCLUSION:
Hearing loss after completing therapy should be corrected for age-related hearing deterioration to reveal the true extent to which the loss is a therapeutic complication. Both the radiation modality used and the dose were significantly associated with hearing loss.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
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Neoplasias Nasofaríngeas
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Radioterapia Conformacional
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Radioterapia de Intensidade Modulada
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Perda Auditiva
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biomed Res Int
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Taiwan