Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Carcinogenesis
; 36(10): 1085-93, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26354776
ABSTRACT
Chronic inflammation contributes to cancer development via multiple mechanisms. One potential mechanism is that chronic inflammation can generate an immunosuppressive microenvironment that allows advantages for tumor formation and progression. The immunosuppressive environment in certain chronic inflammatory diseases and solid cancers is characterized by accumulation of proinflammatory mediators, infiltration of immune suppressor cells and activation of immune checkpoint pathways in effector T cells. In this review, we highlight recent advances in our understanding of how immunosuppression contributes to cancer and how proinflammatory mediators induce the immunosuppressive microenvironment via induction of immunosuppressive cells and activation of immune checkpoint pathways.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Microambiente Tumoral
/
Inflamação
/
Melanoma
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Carcinogenesis
Ano de publicação:
2015
Tipo de documento:
Article