Enantiospecific C-H Activation Using Ruthenium Nanocatalysts.
Angew Chem Int Ed Engl
; 54(36): 10474-7, 2015 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-26371960
ABSTRACT
The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.
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MEDLINE
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En
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Angew Chem Int Ed Engl
Ano de publicação:
2015
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Article