Smoothened Regulation: A Tale of Two Signals.
Trends Pharmacol Sci
; 37(1): 62-72, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26432668
ABSTRACT
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the signal transducer of the developmentally and therapeutically relevant Hedgehog (Hh) pathway. Although recent structural analyses have advanced our understanding of Smo biology, several questions remain. Chief among them are the identity of its natural ligand, the regulatory processes controlling its activation, and the mechanisms by which it signals to downstream effectors. In this review, we discuss recent discoveries from multiple model systems that have set the stage for solving these mysteries. We focus on the roles of distinct Smo functional domains, post-translational modifications, and trafficking, and conclude by discussing their contributions to signal output.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptores Acoplados a Proteínas G
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos