Reward related neurotransmitter changes in a model of depression: An in vivo microdialysis study.
World J Biol Psychiatry
; 16(7): 521-35, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26444572
ABSTRACT
OBJECTIVES:
The self-medication hypothesis assumes that symptoms related to potential monoaminergic deficits in depression may be relieved by drug abuse. The aim of this study was to elucidate the neurotransmitter changes in a rat model of depression by measuring their levels in the nucleus accumbens shell, which is typically involved in the drug of abuse acquisition mechanism.METHODS:
Depression was modelled by the olfactory bulbectomy (OBX) in Wistar male rats. In vivo microdialysis was performed, starting from the baseline and following after a single methamphetamine injection and behaviour was monitored. The determination of neurotransmitters and their metabolites was performed by high-performance liquid chromatography combined with mass spectrometry.RESULTS:
OBX animals had lower basal levels of dopamine and serotonin and their metabolites. However, γ-aminobutyric acid (GABA) and glutamate levels were increased. The methamphetamine injection induced stronger dopamine and serotonin release in the OBX rats and lower release of glutamate in comparison with sham-operated rats; GABA levels did not differ significantly.CONCLUSIONS:
This study provides an evidence of mesolimbic neurotransmitter changes in the rat model of depression which may elucidate mechanisms underlying intravenous self-administration studies in which OBX rats were demonstrated to have higher drug intake in comparison to intact controls.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Recompensa
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Dopaminérgicos
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Neurotransmissores
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Depressão
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Metanfetamina
Limite:
Animals
Idioma:
En
Revista:
World J Biol Psychiatry
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
República Tcheca