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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.
Srikannathasan, Velupillai; Wohlkonig, Alexandre; Shillings, Anthony; Singh, Onkar; Chan, Pan F; Huang, Jianzhong; Gwynn, Michael N; Fosberry, Andrew P; Homes, Paul; Hibbs, Martin; Theobald, Andrew J; Spitzfaden, Claus; Bax, Benjamin D.
Afiliação
  • Srikannathasan V; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Wohlkonig A; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Shillings A; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Singh O; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Chan PF; Antibacterial Discovery Performance Unit, Infectious Diseases Medicines Discovery and Development, GlaxoSmithKline, 1250 Collegeville Road, Collegeville, PA 19426, USA.
  • Huang J; Antibacterial Discovery Performance Unit, Infectious Diseases Medicines Discovery and Development, GlaxoSmithKline, 1250 Collegeville Road, Collegeville, PA 19426, USA.
  • Gwynn MN; Antibacterial Discovery Performance Unit, Infectious Diseases Medicines Discovery and Development, GlaxoSmithKline, 1250 Collegeville Road, Collegeville, PA 19426, USA.
  • Fosberry AP; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Homes P; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Hibbs M; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Theobald AJ; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Spitzfaden C; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
  • Bax BD; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, England.
Acta Crystallogr F Struct Biol Commun ; 71(Pt 10): 1242-6, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26457513
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Compostos de Espiro / Staphylococcus aureus / Fluoroquinolonas / DNA Girase / Etoposídeo / Clivagem do DNA / Compostos Heterocíclicos de 4 ou mais Anéis Idioma: En Revista: Acta Crystallogr F Struct Biol Commun Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Compostos de Espiro / Staphylococcus aureus / Fluoroquinolonas / DNA Girase / Etoposídeo / Clivagem do DNA / Compostos Heterocíclicos de 4 ou mais Anéis Idioma: En Revista: Acta Crystallogr F Struct Biol Commun Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido