Relationship between cutaneous polyarteritis nodosa (cPAN) and macular lymphocytic arteritis (MLA): Blinded histologic assessment of 35 cPAN cases.
J Am Acad Dermatol
; 73(6): 1013-20, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26464220
ABSTRACT
BACKGROUND:
Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no disruption of the internal elastic lamina).OBJECTIVE:
We sought to assess the frequency of clinical and histologic features of MLA in patients with cPAN.METHODS:
This was a monocentric retrospective analysis of patients given the diagnosis of cPAN with blinded assessment of skin biopsy specimens.RESULTS:
All 35 patients included had an infiltrated livedo, nodules, or both. Ulceration was rare. Erythematous or pigmented lesions were present in 54% of patients. Predominantly lymphocytic arteritis, a paucity of neutrophils, concentric fibrin ring, and absence of internal lamina elastic disruption were present in 60%, 20%, 18%, and 23% of patients, respectively. Median follow-up was 11 years. None of the patients had systemic involvement, and 57% had a complete remission. The incidence of complete remission was not different between patients having a predominant lymphocyte infiltrate or few neutrophils.LIMITATIONS:
This was a retrospective, monocentric study without a control group of patients with MLA.CONCLUSIONS:
Our data do not favor the classification of cPAN and MLA as distinct entities.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Poliarterite Nodosa
/
Arterite
/
Linfócitos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
França