Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat.

Worley, Rachel Rogers; Fisher, Jeffrey

Worley, Rachel Rogers; Fisher, Jeffrey.

Afiliação

Worley RR; Agency for Toxic Substances and Disease Registry, Division of Community Health Investigations, 4770 Buford Highway, Atlanta, GA 30341, United States; Interdisciplinary Toxicology Program, University of Georgia, 341 Pharmacy South, Athens, GA 30602, United States. Electronic address: idz7@cdc.gov.
Fisher J; Interdisciplinary Toxicology Program, University of Georgia, 341 Pharmacy South, Athens, GA 30602, United States; Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States.

Toxicol Appl Pharmacol ; 289(3): 428-41, 2015 Dec 15.

Article em En | MEDLINE | ID: mdl-26522833

Assuntos

Caprilatos/metabolismo; Fluorocarbonos/metabolismo; Túbulos Renais Proximais/metabolismo; Túbulos Renais Proximais/fisiologia; Transportadores de Ânions Orgânicos/metabolismo; Reabsorção Renal/fisiologia; Animais; Feminino; Masculino; Proteínas de Membrana Transportadoras/metabolismo; Ratos; Ratos Sprague-Dawley; Ratos Wistar; Caracteres Sexuais

Palavras-chave

IVIVE; Oat1; Oat3; Oatp1a1; PBPK; PFOA

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Caprilatos / Transportadores de Ânions Orgânicos / Reabsorção Renal / Fluorocarbonos / Túbulos Renais Proximais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2015 Tipo de documento: Article

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