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Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor.
Ueki, Ryosuke; Ueki, Ayaka; Kanda, Naoto; Sando, Shinsuke.
Afiliação
  • Ueki R; Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).
  • Ueki A; Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).
  • Kanda N; Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).
  • Sando S; Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan). ssando@chembio.t.u-tokyo.ac.jp.
Angew Chem Int Ed Engl ; 55(2): 579-82, 2016 Jan 11.
Article em En | MEDLINE | ID: mdl-26592704
Oligonucleotide-based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss-0, which was composed solely of 100-mer single-stranded DNA, exhibited nanomolar potency. Aptamer ss-0 reproduced HGF-induced cellular behaviors, including migration and proliferation. The present work sheds light on oligonucleotides as a novel chemical entity for the design of growth factor mimetics.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oligonucleotídeos / Fator de Crescimento de Hepatócito / Mimetismo Molecular Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oligonucleotídeos / Fator de Crescimento de Hepatócito / Mimetismo Molecular Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2016 Tipo de documento: Article