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Extracellular microRNAs in Membrane Vesicles and Non-vesicular Carriers.
Coenen-Stass, Anna M L; Mäger, Imre; Wood, Mathew J A.
Afiliação
  • Coenen-Stass AML; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. anna.coenen-stass@dpag.ox.ac.uk.
  • Mäger I; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.
  • Wood MJA; Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia.
Exp Suppl ; 106: 31-53, 2015.
Article em En | MEDLINE | ID: mdl-26608198
Great excitement has surrounded the finding that small RNAs are stable in various biofluids and carry specific signatures reflecting physiological and pathological states. In this chapter, we briefly describe the impact of this revolutionary discovery and introduce different subclasses of circulating microRNAs based on their mode of transport. Subsequently, we review the current state-of-the art knowledge on microRNA selection for export, secretion and possible uptake mechanisms and their potential function in circulation. Furthermore, we give an overview on the possible use of cell-free microRNAs as biomarkers and as therapeutic targets. Overall, we aim to highlight open questions and address some of the pitfalls of current extracellular RNA research.
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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Exp Suppl Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Exp Suppl Ano de publicação: 2015 Tipo de documento: Article