Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension.

Jalan, Rajiv; De Chiara, Francesco; Balasubramaniyan, Vairappan; Andreola, Fausto; Khetan, Varun; Malago, Massimo; Pinzani, Massimo; Mookerjee, Rajeshwar P; Rombouts, Krista

Jalan, Rajiv; De Chiara, Francesco; Balasubramaniyan, Vairappan; Andreola, Fausto; Khetan, Varun; Malago, Massimo; Pinzani, Massimo; Mookerjee, Rajeshwar P; Rombouts, Krista.

Afiliação

Jalan R; Liver Failure Group, Institute for Liver & Digestive Health, University College of London, Royal Free, London, UK.
De Chiara F; Liver Failure Group, Institute for Liver & Digestive Health, University College of London, Royal Free, London, UK.
Balasubramaniyan V; Liver Failure Group, Institute for Liver & Digestive Health, University College of London, Royal Free, London, UK.
Andreola F; Liver Failure Group, Institute for Liver & Digestive Health, University College of London, Royal Free, London, UK.
Khetan V; Liver Failure Group, Institute for Liver & Digestive Health, University College of London, Royal Free, London, UK.
Malago M; Division of Surgery, University College London, Royal Free, London, UK.
Pinzani M; Regenerative Medicine & Fibrosis Group, Institute for Liver & Digestive Health, University College London, Royal Free, London, UK.
Mookerjee RP; Liver Failure Group, Institute for Liver & Digestive Health, University College of London, Royal Free, London, UK. Electronic address: r.mookerjee@ucl.ac.uk.
Rombouts K; Regenerative Medicine & Fibrosis Group, Institute for Liver & Digestive Health, University College London, Royal Free, London, UK. Electronic address: k.rombouts@ucl.ac.uk.

J Hepatol ; 64(4): 823-33, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26654994

Assuntos

Amônia/farmacologia; Células Estreladas do Fígado/efeitos dos fármacos; Hipertensão Portal/tratamento farmacológico; Amônia/antagonistas & inibidores; Animais; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Retículo Endoplasmático/patologia; Células Estreladas do Fígado/patologia; Humanos; Masculino; Ornitina/análogos & derivados; Ornitina/uso terapêutico; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

(BDL); (ER); (GS); (HE); (OP); (hHSC); Ammonia; Bile duct ligation; Endoplasmic reticulum stress; Glutamine synthetase; Hepatic encephalopathy; Human hepatic stellate cells; Ornithine phenylacetate; Oxidative stress

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Células Estreladas do Fígado / Amônia / Hipertensão Portal Limite: Animals / Humans / Male Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2016 Tipo de documento: Article

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