Epigenetic targets in cancer and aging: dietary and therapeutic interventions.
Expert Opin Ther Targets
; 20(6): 689-703, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-26667209
ABSTRACT
INTRODUCTION:
Epigenetic regulation plays a critical role in normal growth and embryonic development by controlling the transcriptional activities of several genes. A growing number of epigenetic changes have been reported in the regulation of key genes involved in cancer and aging. Drugs with epigenetic modulatory activities, mainly histone deacetylase and DNA methyltransferase inhibitors, have received wider attention in aging and cancer research. AREAS COVERED In this review, we summarize the major epigenetic alterations in cancer and aging, with special emphasis on possible therapeutic targets and interventions by dietary as well as bioactive phytochemicals. EXPERT OPINION Some epigenetic-targeting drugs have received FDA approval and many others are undergoing different phases of clinical trials for cancer therapy. In addition to the synthetic compounds, several bioactive phytochemicals and dietary interventions, such as caloric restriction, have been shown to possess epigenetic modulatory activities in multiple cancers. These epigenetic modulators have been shown to delay aging and minimize the risk of cancer both in preclinical as well as clinical models. Therefore, knowledge of bioactive phytochemicals along with dietary interventions can be utilized for cancer prevention and therapy both alone and with existing drugs to achieve optimum efficacy.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Epigênese Genética
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Expert Opin Ther Targets
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Índia