Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses.
Clin Transl Immunology
; 4(10): e43, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26682051
ABSTRACT
The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides' clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Clin Transl Immunology
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Austrália