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Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers.
Chan, Miu Shan; Tam, Dick Yan; Dai, Ziwen; Liu, Ling Sum; Ho, Jonathan Weng-Thim; Chan, Man Lee; Xu, Di; Wong, Man Shing; Tin, Chung; Lo, Pik Kwan.
Afiliação
  • Chan MS; Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
  • Tam DY; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
  • Dai Z; Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
  • Liu LS; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
  • Ho JW; Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
  • Chan ML; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
  • Xu D; Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
  • Wong MS; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
  • Tin C; Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
  • Lo PK; Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
Small ; 12(6): 770-81, 2016 Feb 10.
Article em En | MEDLINE | ID: mdl-26690974
ABSTRACT
The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tensoativos / Portadores de Fármacos / Doxorrubicina / Nanopartículas / Mitocôndrias Limite: Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tensoativos / Portadores de Fármacos / Doxorrubicina / Nanopartículas / Mitocôndrias Limite: Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China