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ß-lactam substituted polycyclic fused pyrrolidine/pyrrolizidine derivatives eradicate C. albicans in an ex vivo human dentinal tubule model by inhibiting sterol 14-α demethylase and cAMP pathway.
Gowri, Meiyazhagan; Sofi Beaula, Winfred; Biswal, Jayashree; Dhamodharan, Prabhu; Saiharish, Raghavan; Rohan prasad, Surabi; Pitani, Ravishankar; Kandaswamy, Deivanayagam; Raghunathan, Ragavachary; Jeyakanthan, Jeyaraman; Rayala, Suresh K; Venkatraman, Ganesh.
Afiliação
  • Gowri M; Department of Human Genetics, College of Biomedical Sciences, Technology & Research, Sri Ramachandra University, Porur, Chennai- 600 116, India.
  • Sofi Beaula W; Department of Human Genetics, College of Biomedical Sciences, Technology & Research, Sri Ramachandra University, Porur, Chennai- 600 116, India.
  • Biswal J; Department of Bioinformatics, Alagappa University, Karaikudi- 630003, India.
  • Dhamodharan P; Department of Bioinformatics, Alagappa University, Karaikudi- 630003, India.
  • Saiharish R; Department of Medicinal Chemistry, College of Biomedical Sciences, Technology & Research,Sri Ramachandra University, Porur, Chennai- 600 116, India.
  • Rohan prasad S; Department of Biotechnology, Indian Institute of Technology, Madras (IIT M), Chennai- 600 025, India.
  • Pitani R; Department of Community Medicine, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai-600 116, India.
  • Kandaswamy D; Department of Conservative Dentistry and Endodontics, College of Dental Sciences, Sri Ramachandra University, Porur, Chennai-600 116, India.
  • Raghunathan R; Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai- 600 025, India.
  • Jeyakanthan J; Department of Bioinformatics, Alagappa University, Karaikudi- 630003, India. Electronic address: jjkanthan@gmail.com.
  • Rayala SK; Department of Biotechnology, Indian Institute of Technology, Madras (IIT M), Chennai- 600 025, India. Electronic address: rayala@iitm.ac.in.
  • Venkatraman G; Department of Human Genetics, College of Biomedical Sciences, Technology & Research, Sri Ramachandra University, Porur, Chennai- 600 116, India. Electronic address: ganeshv@sriramachandra.edu.
Biochim Biophys Acta ; 1860(4): 636-47, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26723175
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Candida albicans / Candidíase / Sistemas do Segundo Mensageiro / AMP Cíclico / Cavidade Pulpar / Beta-Lactamas / Esterol 14-Desmetilase / Inibidores de 14-alfa Desmetilase / Modelos Biológicos / Antifúngicos Limite: Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Índia
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Candida albicans / Candidíase / Sistemas do Segundo Mensageiro / AMP Cíclico / Cavidade Pulpar / Beta-Lactamas / Esterol 14-Desmetilase / Inibidores de 14-alfa Desmetilase / Modelos Biológicos / Antifúngicos Limite: Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Índia