Expedient Synthesis of (+)-Lycopalhineâ
A.
Angew Chem Int Ed Engl
; 55(6): 2191-4, 2016 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-26748762
ABSTRACT
Two amino acids play a key role in the first total synthesis of lycopalhineâ
A. L-glutamic acid serves as a convenient chiral starting material for the 13-step synthesis, and l-proline promotes an unusual 5-endo-trig Mannich cyclization that generates the central pyrrolidine ring of the Lycopodium alkaloid. The bicyclo[3.3.0]octanol moiety of the molecule is formed through an intramolecular aldol addition that may occur spontaneously in nature.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Alcaloides
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha