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Cardiovascular and renal effects of calcitonin gene-related peptide in hypertensive dogs.
Verburg, K M; Freeman, R H; Villarreal, D; Brands, M W.
Afiliação
  • Verburg KM; Department of Physiology, University of Missouri School of Medicine, Columbia, MO.
Peptides ; 10(3): 663-9, 1989.
Article em En | MEDLINE | ID: mdl-2674914
The systemic cardiovascular and renal effects of synthetic beta-human calcitonin gene-related peptide (beta-hCGRP) were examined in conscious normotensive and one-kidney one-clip (1K-1C) hypertensive dogs. beta-hCGRP was infused intravenously at 10 and 50 ng/kg/min for 75-min periods each. Mean arterial pressure did not change significantly (p greater than 0.05) in either group during low dose infusion of beta-hCGRP, but infusion of beta-hCGRP at 50 ng/kg/min produced a fall in mean arterial pressure from 140 +/- 4 to 116 +/- 6 mmHg (p less than 0.05) in the hypertensive dogs (n = 4) and from 100 +/- 4 to 78 +/- 3 mmHg (p less than 0.05) in the normotensive dogs (n = 4). Heart rates increased significantly during infusion of beta-hCGRP in both groups. Also, renal sodium and potassium excretion decreased (p less than 0.05) in the two groups at both the low and high doses of beta-hCGRP. Creatinine clearance was unchanged in normal dogs and decreased (p less than 0.05) in 1K-1C hypertensive dogs at the high rate of beta-hCGRP infusion. The clearance of p-aminohippurate increased approximately 20% (p less than 0.05) in both groups with the low dose infusion of beta-hCGRP but further increases were elicited only in the normotensive dogs in response to the elevation in the beta-hCGRP infusion rate. Plasma renin and aldosterone levels increased (p less than 0.05) above control levels during the maximum hypotensive response to beta-hCGRP infusion in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
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Bases de dados: MEDLINE Assunto principal: Circulação Renal / Neuropeptídeos / Calcitonina / Hipertensão Renovascular / Rim Limite: Animals Idioma: En Revista: Peptides Ano de publicação: 1989 Tipo de documento: Article
Buscar no Google
Bases de dados: MEDLINE Assunto principal: Circulação Renal / Neuropeptídeos / Calcitonina / Hipertensão Renovascular / Rim Limite: Animals Idioma: En Revista: Peptides Ano de publicação: 1989 Tipo de documento: Article