Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae.
Aging Cell
; 15(2): 317-24, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26762766
ABSTRACT
Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here, we show that yeast disomic for a single native yeast chromosome generally have a decreased replicative lifespan. In addition, the extent of this lifespan deficit correlates with the size of the extra chromosome. We identified a mutation in BUL1 that rescues both the lifespan deficit and a protein trafficking defect in yeast disomic for chromosome 5. Bul1 is an E4 ubiquitin ligase adaptor involved in a protein quality control pathway that targets membrane proteins for endocytosis and destruction in the lysosomal vacuole, thereby maintaining protein homeostasis. Concurrent suppression of the aging and trafficking phenotypes suggests that disrupted membrane protein homeostasis in aneuploid yeast may contribute to their accelerated aging. The data reported here demonstrate that aneuploidy can impair protein homeostasis, shorten lifespan, and may contribute to age-associated phenotypes.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Aneuploidia
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos