Low sulfide levels and a high degree of cystathionine ß-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat.
Redox Biol
; 8: 192-8, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-26803480
ABSTRACT
Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine ß-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
S-Adenosilmetionina
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Envelhecimento
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Cistationina beta-Sintase
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Sulfeto de Hidrogênio
Limite:
Animals
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2016
Tipo de documento:
Article