High-Throughput Screen in <i>Cryptococcus neoformans</i> Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.

Hartland, Kate; Pu, Jun; Palmer, Michelle; Dandapani, Sivaraman; Moquist, Philip N; Munoz, Benito; DiDone, Louis; Schreiber, Stuart L; Krysan, Damian J

High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.

Hartland, Kate; Pu, Jun; Palmer, Michelle; Dandapani, Sivaraman; Moquist, Philip N; Munoz, Benito; DiDone, Louis; Schreiber, Stuart L; Krysan, Damian J.

Afiliação

Hartland K; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Pu J; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Palmer M; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Dandapani S; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Moquist PN; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Munoz B; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
DiDone L; Department of Pediatrics and Department of Microbiology/Immunology, University of Rochester School of Medicine and Dentistry , 601 Elmwood Avenue, Rochester, New York 14642, United States.
Schreiber SL; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Krysan DJ; Department of Pediatrics and Department of Microbiology/Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, United States; Department of Pediatrics and Department of Microbiology/Immunology, University of Rochester School of Medicine a

ACS Infect Dis ; 2(1): 93-102, 2016 Jan 08.

Article em En | MEDLINE | ID: mdl-26807437

Palavras-chave

Cryptococcus neoformans; antifungal; cell wall integrity pathway; high-throughput screening; mitogen-activated protein kinase; yeast cell wall

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: ACS Infect Dis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos