Complex I function in mitochondrial supercomplexes.
Biochim Biophys Acta
; 1857(7): 991-1000, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-26820434
ABSTRACT
This review discusses the functional properties of mitochondrial Complex I originating from its presence in an assembled form as a supercomplex comprising Complex III and Complex IV in stoichiometric ratios. In particular several lines of evidence are presented favouring the concept that electron transfer from Complex I to Complex III is operated by channelling of electrons through Coenzyme Q molecules bound to the supercomplex, in contrast with the hypothesis that the transfer of reducing equivalents from Complex I to Complex III occurs via random diffusion of the Coenzyme Q molecules in the lipid bilayer. Furthermore, another property provided by the supercomplex assembly is the control of generation of reactive oxygen species by Complex I. This article is part of a Special Issue entitled Respiratory Complex I, edited by Volker Zickermann and Ulrich Brandt.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ubiquinona
/
Espécies Reativas de Oxigênio
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Complexo I de Transporte de Elétrons
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Mitocôndrias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2016
Tipo de documento:
Article