Modeling the Influence of Fatty Acid Incorporation on Mesophase Formation in Amphiphilic Therapeutic Delivery Systems.
Mol Pharm
; 13(3): 996-1003, 2016 03 07.
Article
em En
| MEDLINE
| ID: mdl-26824251
ABSTRACT
Dispersed amphiphile-fatty acid systems are of great interest in drug delivery and gene therapies because of their potential for triggered release of their payload. The mesophase behavior of these systems is extremely complex and is affected by environmental factors such as drug loading, percentage and nature of incorporated fatty acids, temperature, pH, and so forth. It is important to study phase behavior of amphiphilic materials as the mesophases directly influence the release rate of the incorporated drugs. We describe a robust machine learning method for predicting the phase behavior of these systems. We have developed models for each mesophase that simultaneous and reliably model the effects of amphiphile and fatty acid structure, concentration, and temperature and that make accurate predictions of these mesophases for conditions not used to train the models.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Água
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Sistemas de Liberação de Medicamentos
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Nanopartículas
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Ácidos Graxos
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Glicerídeos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Mol Pharm
Assunto da revista:
BIOLOGIA MOLECULAR
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FARMACIA
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FARMACOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália