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Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
Ferreira de Freitas, Renato; Eram, Mohammad S; Szewczyk, Magdalena M; Steuber, Holger; Smil, David; Wu, Hong; Li, Fengling; Senisterra, Guillermo; Dong, Aiping; Brown, Peter J; Hitchcock, Marion; Moosmayer, Dieter; Stegmann, Christian M; Egner, Ursula; Arrowsmith, Cheryl; Barsyte-Lovejoy, Dalia; Vedadi, Masoud; Schapira, Matthieu.
Afiliação
  • Ferreira de Freitas R; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Eram MS; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Szewczyk MM; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Steuber H; Pharmaceuticals Division, Bayer Pharma AG, 13353 Berlin, Germany.
  • Smil D; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Wu H; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Li F; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Senisterra G; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Dong A; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Brown PJ; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Hitchcock M; Pharmaceuticals Division, Bayer Pharma AG, 13353 Berlin, Germany.
  • Moosmayer D; Pharmaceuticals Division, Bayer Pharma AG, 13353 Berlin, Germany.
  • Stegmann CM; Pharmaceuticals Division, Bayer Pharma AG, 13353 Berlin, Germany.
  • Egner U; Pharmaceuticals Division, Bayer Pharma AG, 13353 Berlin, Germany.
  • Arrowsmith C; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Barsyte-Lovejoy D; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Vedadi M; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
  • Schapira M; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.
J Med Chem ; 59(3): 1176-83, 2016 Feb 11.
Article em En | MEDLINE | ID: mdl-26824386
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Proteínas Repressoras / Inibidores Enzimáticos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Proteínas Repressoras / Inibidores Enzimáticos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá