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Gleason score stratification according to age at diagnosis in 1028 men.
Pepe, Pietro; Pennisi, Michele.
Afiliação
  • Pepe P; Urology Unit, Cannizzaro Hospital, Catania, Italy.
  • Pennisi M; Urology Unit, Cannizzaro Hospital, Catania, Italy.
Contemp Oncol (Pozn) ; 19(6): 471-3, 2015.
Article em En | MEDLINE | ID: mdl-26843845
AIM OF THE STUDY: Gleason score stratification according to age at diagnosis has been retrospectively evaluated in 1028 men with biopsy-proven prostate cancer (PCa). MATERIAL AND METHODS: From January 2006 to December 2014, 2435 Caucasian men aged between 37 and 92 years underwent transperineal prostate biopsy for suspicion of PCa. The indications were as follows: abnormal digital rectal examination (DRE), PSA values > 10 ng/ml or between 4.1-10 or 2.6-4 ng/ml, with free/total PSA < 25% and < 20%, respectively. RESULTS: In 1028 (42.2%) patients with median PSA of 9.6 ng/ml a PCa was found (median age 62.3 years; range: 42-92 years); 757 (73.7%) vs. 271 (26.3%) men had a T1c vs. T2 clinical stage, respectively. Median Gleason score was 7 (range: 6-10). The Gleason score progressively increased with the age of the patients at diagnosis, and a significantly correlation between Gleason score ≥ 8 and men older than 80 years was demonstrated (p = 0.0001). CONCLUSIONS: The detection rate of aggressiveness of PCa progressively increased with the age at diagnosis; Gleason score ≥ 8 was more frequently diagnosed in men older than 80 years with PSA values > 10 ng/ml (about 80% of the cases) and abnormal DRE (about 60% of the cases).
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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Contemp Oncol (Pozn) Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Contemp Oncol (Pozn) Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Itália