Craniosynostosis Following Fetal Methotrexate Exposure.
J Craniofac Surg
; 27(2): 450-2, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26890458
ABSTRACT
Methotrexate (MTX) is an antimetabolite, folic acid antagonist that inhibits purine nucleotide production, DNA synthesis, and cellular proliferation. Despite widespread therapeutic uses, MTX remains a potent teratogen. Methotrexate embryopathy encompasses multiorgan system dysfunction, including intrauterine growth restriction as well as cardiac, craniofacial, renal, genital, and skeletal abnormalities. Effects of MTX exposure on fetal development continue to be described. This series of 4 patients with MTX-associated craniosynostosis represents the largest published association between prenatal MTX exposure and premature cranial suture closure.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Metotrexato
/
Craniossinostoses
/
Lesões Pré-Natais
/
Doenças Fetais
/
Antagonistas do Ácido Fólico
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Craniofac Surg
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article