Recoding a cocaine-place memory engram to a neutral engram in the hippocampus.
Nat Neurosci
; 19(4): 564-7, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26900924
ABSTRACT
The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Cocaína
/
Condicionamento Psicológico
/
Optogenética
/
Hipocampo
/
Memória
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido