Signal intensity change on unenhanced T1-weighted images in dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide.
Eur Radiol
; 26(11): 4080-4088, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-26911888
ABSTRACT
OBJECTIVES:
To evaluate the impact of previous administration of gadodiamide and neural tissue gadolinium deposition in patients who received gadobenate dimeglumine.METHODS:
Our population included 62 patients who underwent at least three administrations of gadobenate dimeglumine, plus an additional contrast-enhanced last MRI for reference, divided into two groups group 1, patients who in addition to gadobenate dimeglumine administrations had prior exposure to multiple doses of gadodiamide; group 2, patients without previous exposure to other gadolinium-based contrast agent (GBCAs). Quantitative analysis was performed on the first and last gadobenate dimeglumine MRIs in both groups. Dentate nucleus-to-middle cerebellar peduncle signal intensity ratios (DN/MCP) and relative change (RC) in signal over time were calculated and compared between groups using generalized additive model.RESULTS:
Group 1 showed significant increase in baseline and follow-up DN/MCP compared to group 2 (p < 0.0001). The RC DN/MCP showed a non-statistically significant trend towards an increase in patients who underwent previous gadodiamide (p = 0.0735).CONCLUSION:
There is increased T1 signal change over time in patients who underwent gadobenate dimeglumine and had received prior gadodiamide compared to those without known exposure to previous gadodiamide. A potentiating effect from prior gadodiamide on subsequent administered gadobenate dimeglumine may occur. KEY POINTS ⢠Neural gadolinium deposition is associated with multiple administrations of less stable GBCAs. ⢠Less stable GBCA effect on subsequent more stable GBCA administrations is undetermined. ⢠Significant increase of DN/MCP was seen in patients with previous gadodiamide exposure. ⢠RC DN/MCP showed a non-significant increase in patients who received previous gadodiamide. ⢠Potentiating effects from prior gadodiamide on subsequent administered gadobenate dimeglumine may occur.Palavras-chave
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Bases de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Núcleos Cerebelares
/
Meios de Contraste
/
Gadolínio DTPA
/
Gadolínio
/
Meglumina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos