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PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.
Babichev, Yael; Kabaroff, Leah; Datti, Alessandro; Uehling, David; Isaac, Methvin; Al-Awar, Rima; Prakesch, Michael; Sun, Ren X; Boutros, Paul C; Venier, Rosemarie; Dickson, Brendan C; Gladdy, Rebecca A.
Afiliação
  • Babichev Y; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, Canada. babichev@lunenfeld.ca.
  • Kabaroff L; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, Canada. kabaroff@lunenfeld.ca.
  • Datti A; Sinai-McLaughlin Assay and Robotic Technologies Facility, Lunenfeld-Tanenbaum Research Institute, Toronto, M5G 1X5, Canada. datti@lunenfeld.ca.
  • Uehling D; Department of Agricultural, Food, and Environmental Sciences, University of Perugia, 06121, Perugia, Italy. datti@lunenfeld.ca.
  • Isaac M; Drug Discovery Group, Ontario Institute for Cancer Research, Toronto, M5G 0A3, Canada. David.Uehling@oicr.on.ca.
  • Al-Awar R; Drug Discovery Group, Ontario Institute for Cancer Research, Toronto, M5G 0A3, Canada. Methvin.Isaac@oicr.on.ca.
  • Prakesch M; Drug Discovery Group, Ontario Institute for Cancer Research, Toronto, M5G 0A3, Canada. Rima.AlAwar@oicr.on.ca.
  • Sun RX; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada. Rima.AlAwar@oicr.on.ca.
  • Boutros PC; Drug Discovery Group, Ontario Institute for Cancer Research, Toronto, M5G 0A3, Canada. Michael.Prakesch@oicr.on.ca.
  • Venier R; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada. Ren.Sun@oicr.on.ca.
  • Dickson BC; Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, M5G 0A3, ON, Canada. Ren.Sun@oicr.on.ca.
  • Gladdy RA; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada. Paul.Boutros@oicr.on.ca.
J Transl Med ; 14: 67, 2016 Mar 08.
Article em En | MEDLINE | ID: mdl-26952093
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Doxorrubicina / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase / Leiomiossarcoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Transl Med Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Doxorrubicina / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase / Leiomiossarcoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Transl Med Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá