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Advanced Molecular Detection of Malarone Resistance.
Talundzic, Eldin; Plucinski, Mateusz M; Biliya, Shweta; Silva-Flannery, Luciana M; Arguin, Paul M; Halsey, Eric S; Barnwell, John W; Vannberg, Fredrik; Udhayakumar, Venkatachalam.
Afiliação
  • Talundzic E; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Atlanta Research and Education Foundation, Veterans Affairs Medical Center, Atlanta, Georgia, USA etalundzic@cdc.gov.
  • Plucinski MM; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA President's Malaria Initiative, Atlanta, Georgia, USA.
  • Biliya S; School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.
  • Silva-Flannery LM; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Atlanta Research and Education Foundation, Veterans Affairs Medical Center, Atlanta, Georgia, USA.
  • Arguin PM; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Halsey ES; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA President's Malaria Initiative, Atlanta, Georgia, USA.
  • Barnwell JW; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Vannberg F; School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.
  • Udhayakumar V; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Antimicrob Agents Chemother ; 60(6): 3821-3, 2016 06.
Article em En | MEDLINE | ID: mdl-27001821
ABSTRACT
The rapid emergence of drug-resistant malaria parasites during the course of an infection remains a major challenge for providing accurate treatment guidelines. This is particularly important in cases of malaria treatment failure. Using a previously well-characterized case of malaria treatment failure, we show the utility of using next-generation sequencing for early detection of the rise and selection of a previously reported atovaquone-proguanil (malarone) drug resistance-associated mutation.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Plasmodium falciparum / Resistência a Medicamentos / Proteínas de Protozoários / Citocromos b / Mutação Tipo de estudo: Diagnostic_studies / Guideline / Screening_studies Limite: Adult / Humans / Male País/Região como assunto: Africa / America do norte Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Plasmodium falciparum / Resistência a Medicamentos / Proteínas de Protozoários / Citocromos b / Mutação Tipo de estudo: Diagnostic_studies / Guideline / Screening_studies Limite: Adult / Humans / Male País/Região como assunto: Africa / America do norte Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos