Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts.

Bhadury, Joydeep; Einarsdottir, Berglind O; Podraza, Agnieszka; Bagge, Roger Olofsson; Stierner, Ulrika; Ny, Lars; Dávila López, Marcela; Nilsson, Jonas A

Bhadury, Joydeep; Einarsdottir, Berglind O; Podraza, Agnieszka; Bagge, Roger Olofsson; Stierner, Ulrika; Ny, Lars; Dávila López, Marcela; Nilsson, Jonas A.

Afiliação

Bhadury J; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Einarsdottir BO; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Podraza A; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Bagge RO; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Stierner U; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Ny L; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Dávila López M; The Bioinformatics Core Facility at the University of Gothenburg, Gothenburg, Sweden.
Nilsson JA; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Oncotarget ; 7(17): 23801-11, 2016 Apr 26.

Article em En | MEDLINE | ID: mdl-27009863

Assuntos

Biomarcadores Tumorais/genética; Regulação Neoplásica da Expressão Gênica; Hipóxia/fisiopatologia; Melanoma/genética; Melanoma/patologia; MicroRNAs/genética; Transcriptoma; Animais; Antineoplásicos/farmacologia; Apoptose; Proliferação de Células; Humanos; Melanoma/tratamento farmacológico; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

MEK inhibitor; hypoxia; melanoma; miR210; xenografts

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / MicroRNAs / Transcriptoma / Melanoma / Hipóxia Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Suécia

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