Management of Labour and Delivery in a Patient With Acquired Factor VII Deficiency With Inhibitor: A Case Report.
J Obstet Gynaecol Can
; 38(2): 160-3, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-27032741
BACKGROUND: Acquired factor VII (FVII) deficiency with inhibitor increases the risk of hemorrhage during pregnancy. However, there are no published reports guiding its management in the peripartum period. CASE: A 24-year-old woman with inhibitory antibodies to FVII delivered at 34 weeks of gestation. The patient was administered recombinant factor VIIa (rFVIIa) and tranexamic acid. There were no bleeding-related complications; however, the FVII level was supratherapeutic. The patient returned during a second pregnancy. A reduced dose of rFVIIa was administered. The delivery was complicated by postpartum hemorrhage, which resolved with the addition of uterotonic agents. CONCLUSION: Recombinant FVIIa and tranexamic acid offer an effective peripartum treatment in women with inhibitory antibody to FVII. Further research should delineate the optimal time of administration.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
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Ácido Tranexâmico
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Hemostáticos
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Fator VIIa
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Deficiência do Fator VII
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Obstet Gynaecol Can
Assunto da revista:
GINECOLOGIA
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OBSTETRICIA
Ano de publicação:
2016
Tipo de documento:
Article