Allostery and Biased Agonism at Class B G Protein-Coupled Receptors.

Wootten, Denise; Miller, Laurence J; Koole, Cassandra; Christopoulos, Arthur; Sexton, Patrick M

Wootten, Denise; Miller, Laurence J; Koole, Cassandra; Christopoulos, Arthur; Sexton, Patrick M.

Afiliação

Wootten D; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville 3052, Victoria, Australia.
Miller LJ; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic , Scottsdale, Arizona 85259, United States.
Koole C; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville 3052, Victoria, Australia.
Christopoulos A; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University , New York, New York 10065, United States.
Sexton PM; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville 3052, Victoria, Australia.

Chem Rev ; 117(1): 111-138, 2017 01 11.

Article em En | MEDLINE | ID: mdl-27040440

Assuntos

Receptores Acoplados a Proteínas G/química; Regulação Alostérica; Dimerização; Receptores Acoplados a Proteínas G/agonistas; Relação Estrutura-Atividade

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Receptores Acoplados a Proteínas G Idioma: En Revista: Chem Rev Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália

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