Magnetic barcode imaging for contrast agents.
Magn Reson Med
; 77(3): 970-978, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27062518
ABSTRACT
PURPOSE:
To demonstrate a new MR imaging approach that unambiguously identifies and quantitates contrast agents based on intrinsic agent properties such as r1 , r2 , r2*, and magnetic susceptibility. The approach is referred to as magnetic barcode imaging (MBI).METHODS:
Targeted and bioresponsive contrast agents were imaged in agarose phantoms to generate T1 , T2 , T2*, and quantitative susceptibility maps. The parameter maps were processed by a machine learning algorithm that is trained to recognize the contrast agents based on these parameters. The output is a quantitative map of contrast agent concentration, identity, and functional state.RESULTS:
MBI allowed the quantitative interpretation of intensities, removed confounding backgrounds, enabled contrast agent multiplexing, and unambiguously detected the activation and binding states of bioresponsive and targeted contrast agents.CONCLUSION:
MBI has the potential to overcome significant limitations in the interpretation, quantitation, and multiplexing of contrast enhancement by MR imaging probes. Magn Reson Med 77970-978, 2017. © 2016 International Society for Magnetic Resonance in Medicine.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Algoritmos
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Imageamento por Ressonância Magnética
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Espectroscopia de Ressonância Magnética
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Técnicas de Sonda Molecular
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Meios de Contraste
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Imagem Molecular
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Idioma:
En
Revista:
Magn Reson Med
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos