The Determinants of Directionality in Transcriptional Initiation.
Trends Genet
; 32(6): 322-333, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27066865
ABSTRACT
A new paradigm has emerged in recent years characterizing transcription initiation as a bidirectional process encompassing a larger proportion of the genome than previously thought. Past concepts of coding genes thinly scattered among a vast background of transcriptionally inert noncoding DNA have been abandoned. A richer picture has taken shape, integrating transcription of coding genes, enhancer RNAs (eRNAs), and various other noncoding transcriptional events. In this review we give an overview of recent studies detailing the mechanisms of RNA polymerase II (RNA Pol II)-based transcriptional initiation and discuss the ways in which transcriptional direction is established as well as its functional implications.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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RNA Polimerase II
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RNA
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Elementos Facilitadores Genéticos
Limite:
Humans
Idioma:
En
Revista:
Trends Genet
Assunto da revista:
GENETICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos