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Prediction of Metabolic Clearance for Low-Turnover Compounds Using Plated Hepatocytes with Enzyme Activity Correction.
Ma, Bennett; Eisenhandler, Roy; Kuo, Yuhsin; Rearden, Paul; Li, Ying; Manley, Peter J; Smith, Sheri; Menzel, Karsten.
Afiliação
  • Ma B; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, West Point, PA, 19486, USA. bennett_ma@merck.com.
  • Eisenhandler R; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, West Point, PA, 19486, USA.
  • Kuo Y; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, West Point, PA, 19486, USA.
  • Rearden P; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, West Point, PA, 19486, USA.
  • Li Y; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ, USA.
  • Manley PJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, USA.
  • Smith S; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, West Point, PA, 19486, USA.
  • Menzel K; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, West Point, PA, 19486, USA.
Eur J Drug Metab Pharmacokinet ; 42(2): 319-326, 2017 Apr.
Article em En | MEDLINE | ID: mdl-27101423
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Hepatócitos / Sistema Enzimático do Citocromo P-450 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Eur J Drug Metab Pharmacokinet Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Hepatócitos / Sistema Enzimático do Citocromo P-450 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Eur J Drug Metab Pharmacokinet Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos