Phosphate responsive regulation provides insights for ESX-5 function in Mycobacterium tuberculosis.
Curr Genet
; 62(4): 759-763, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27105642
ABSTRACT
Pathogenic microbes commonly respond to environmental cues in the host by activating specialized protein secretion systems. Mycobacterium tuberculosis uses the specialized Type VII ESX protein secretion systems to transport a subset of effector proteins. The ESX-5 secretion system is involved in virulence, but both the mechanism of regulation and activating signal were unknown. Our work, reviewed here, has established that the phosphate sensing Pst/SenX3-RegX3 system directly activates ESX-5 secretion in response to phosphate limitation, a relevant environmental signal likely encountered by M. tuberculosis in the host. This review focuses on how elucidation of the ESX-5 regulatory network provides insight into its biological roles, which may include both phosphate acquisition and pathogenesis.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fosfatos
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Proteínas de Bactérias
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Sistemas de Secreção Bacterianos
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Mycobacterium tuberculosis
Limite:
Animals
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Humans
Idioma:
En
Revista:
Curr Genet
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos