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A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.
Han, Buhm; Pouget, Jennie G; Slowikowski, Kamil; Stahl, Eli; Lee, Cue Hyunkyu; Diogo, Dorothee; Hu, Xinli; Park, Yu Rang; Kim, Eunji; Gregersen, Peter K; Dahlqvist, Solbritt Rantapää; Worthington, Jane; Martin, Javier; Eyre, Steve; Klareskog, Lars; Huizinga, Tom; Chen, Wei-Min; Onengut-Gumuscu, Suna; Rich, Stephen S; Wray, Naomi R; Raychaudhuri, Soumya.
Afiliação
  • Han B; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Pouget JG; Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
  • Slowikowski K; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Stahl E; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • Lee CH; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Diogo D; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Hu X; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • Park YR; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Kim E; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Gregersen PK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Dahlqvist SR; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • Worthington J; Bioinformatics and Integrative Genomics, Harvard University, Cambridge, Massachusetts, USA.
  • Martin J; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
  • Eyre S; Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
  • Klareskog L; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Huizinga T; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Chen WM; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • Onengut-Gumuscu S; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Rich SS; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Wray NR; Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA.
  • Raychaudhuri S; Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Nat Genet ; 48(7): 803-10, 2016 07.
Article em En | MEDLINE | ID: mdl-27182969
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Autoimunes / Marcadores Genéticos / Modelos Estatísticos / Polimorfismo de Nucleotídeo Único / Transtorno Depressivo Maior / Diabetes Mellitus Tipo 1 / Pleiotropia Genética Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Autoimunes / Marcadores Genéticos / Modelos Estatísticos / Polimorfismo de Nucleotídeo Único / Transtorno Depressivo Maior / Diabetes Mellitus Tipo 1 / Pleiotropia Genética Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos