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Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.
Strakova, Andrea; Ní Leathlobhair, Máire; Wang, Guo-Dong; Yin, Ting-Ting; Airikkala-Otter, Ilona; Allen, Janice L; Allum, Karen M; Bansse-Issa, Leontine; Bisson, Jocelyn L; Castillo Domracheva, Artemio; de Castro, Karina F; Corrigan, Anne M; Cran, Hugh R; Crawford, Jane T; Cutter, Stephen M; Delgadillo Keenan, Laura; Donelan, Edward M; Faramade, Ibikunle A; Flores Reynoso, Erika; Fotopoulou, Eleni; Fruean, Skye N; Gallardo-Arrieta, Fanny; Glebova, Olga; Häfelin Manrique, Rodrigo F; Henriques, Joaquim Jgp; Ignatenko, Natalia; Koenig, Debbie; Lanza-Perea, Marta; Lobetti, Remo; Lopez Quintana, Adriana M; Losfelt, Thibault; Marino, Gabriele; Martincorena, Inigo; Martínez Castañeda, Simón; Martínez-López, Mayra F; Meyer, Michael; Nakanwagi, Berna; De Nardi, Andrigo B; Neunzig, Winifred; Nixon, Sally J; Onsare, Marsden M; Ortega-Pacheco, Antonio; Peleteiro, Maria C; Pye, Ruth J; Reece, John F; Rojas Gutierrez, Jose; Sadia, Haleema; Schmeling, Sheila K; Shamanova, Olga; Ssuna, Richard K.
Afiliação
  • Strakova A; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Ní Leathlobhair M; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Wang GD; State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Yin TT; State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Airikkala-Otter I; International Training Center, Worldwide Veterinary Service, Aruvankadu, India.
  • Allen JL; Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia.
  • Allum KM; World Vets, Fargo, United States.
  • Bansse-Issa L; Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
  • Bisson JL; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Castillo Domracheva A; Corozal Veterinary Hospital, University of Panama, Panama City, Panama.
  • de Castro KF; Department of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil.
  • Corrigan AM; St. George's University, True Blue, Grenada.
  • Cran HR; The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
  • Crawford JT; Animal Medical Centre, Belize City, Belize.
  • Cutter SM; Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia.
  • Delgadillo Keenan L; Veterinary clinic Sr. Dog's, Guadalajara, Mexico.
  • Donelan EM; Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia.
  • Faramade IA; National Veterinary Research Institute, Vom, Nigeria.
  • Flores Reynoso E; International Fund for Animal Welfare, Quintana Roo, Mexico.
  • Fotopoulou E; Intermunicipal Stray Animals Care Centre, Perama, Greece.
  • Fruean SN; Animal Protection Society of Samoa, Apia, Samoa.
  • Gallardo-Arrieta F; Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
  • Glebova O; Veterinary clinic BIOCONTROL, Moscow, Russia.
  • Häfelin Manrique RF; Veterinary clinic El Roble, Santiago de Chile, Chile.
  • Henriques JJ; OnevetGroup, Centro Veterinário Berna, Lisboa, Portugal.
  • Ignatenko N; Veterinary clinic Zoovetservis, Kiev, Ukraine.
  • Koenig D; World Vets, Fargo, United States.
  • Lanza-Perea M; St. George's University, True Blue, Grenada.
  • Lobetti R; Bryanston Veterinary Hospital, Bryanston, South Africa.
  • Lopez Quintana AM; Veterinary Clinic Lopez Quintana, Maldonado, Uruguay.
  • Losfelt T; Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, France.
  • Marino G; Department of Veterinary Sciences, University of Messina, Messina, Italy.
  • Martincorena I; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
  • Martínez Castañeda S; Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.
  • Martínez-López MF; School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.
  • Meyer M; Touray & Meyer Vet Clinic, Serrekunda, Gambia.
  • Nakanwagi B; The Kampala Veterinary Surgery, Kampala, Uganda.
  • De Nardi AB; Department of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil.
  • Neunzig W; World Vets, Fargo, United States.
  • Nixon SJ; Vets Beyond Borders, The Rocks, Australia.
  • Onsare MM; Aniworld veterinary clinic, Kisumu, Kenya.
  • Ortega-Pacheco A; Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.
  • Peleteiro MC; Interdisciplinary Centre of Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.
  • Pye RJ; Vets Beyond Borders, The Rocks, Australia.
  • Reece JF; Help in Suffering, Jaipur, India.
  • Rojas Gutierrez J; Veterinary clinic Dr José Rojas, Los Andes, Chile.
  • Sadia H; University of Veterinary and Animal Sciences, Lahore, Pakistan.
  • Schmeling SK; Corozal Veterinary Clinic, Corozal Town, Belize.
  • Shamanova O; Veterinary clinic Vetmaster, Ramenskoye, Russia.
  • Ssuna RK; Lilongwe Society for Protection and Care of Animals, Lilongwe, Malawi.
Elife ; 52016 05 17.
Article em En | MEDLINE | ID: mdl-27185408
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Recombinação Genética / Seleção Genética / Variação Genética / Tumores Venéreos Veterinários / Doenças do Cão / Mitocôndrias Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Recombinação Genética / Seleção Genética / Variação Genética / Tumores Venéreos Veterinários / Doenças do Cão / Mitocôndrias Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido