[Occupational Allergies to Trypsin and Chymotrypsin]. / Berufliche Allergien gegen Trypsin und Chymotrypsin.
Pneumologie
; 70(7): 442-5, 2016 Jul.
Article
em De
| MEDLINE
| ID: mdl-27218213
ABSTRACT
Trypsin and chymotrypsin are proteolytic pancreatic enzymes that are secreted as the inactive precursors trypsinogen and chymotrypsinogen, respectively. They have several pharmacological as well as laboratory applications, especially in protein chemistry. Exposure to enzyme dusts has long been known to cause immediate occupational hypersensitivities of the airways. Also trypsin and chymotrypsin are potential inhalable sensitizers, and clear cases of specific airway sensitization caused by trypsin- and chymotrypsin-containing products have been reported by several studies. Positive skin prick and challenge tests as well as specific IgE antibodies have been described. These results and the clinical symptoms usually matched well, suggesting an immunological mechanism of action. Immediate urticarial reactions of the skin due to contact with these enzymes are possible, but there is no clear evidence of allergic cell-mediated delayed eczematous skin reactions.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Hipersensibilidade Respiratória
/
Quimotripsina
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Tripsina
/
Dermatite Alérgica de Contato
/
Doenças Profissionais
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
De
Revista:
Pneumologie
Ano de publicação:
2016
Tipo de documento:
Article