Timing of Hepatitis C Antiviral Therapy in Liver Transplant Recipients With Direct-acting Agents.
Exp Clin Transplant
; 14(3): 243-51, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27221717
ABSTRACT
Chronic hepatitis C virus infection is a substantial health care burden worldwide and is the leading cause of liver transplant in adults. In patients with detectable hepatitis C virus RNA at the time of transplant, interferon-based therapies for hepatitis C virus were poorly tolerated with low virologic response rates. Although reinfection after transplant is inevitable, the recent advent of direct-acting antiviral agents has revolutionized treatment of hepatitis C virus in the pre- and posttransplant settings. These antiviral agents have been shown to have high-sustained virologic response rates, shorter courses of treatment, and decreased frequencies of adverse effects. Here, we review the current literature on the use of direct-acting agents for treatment of patients with hepatitis C virus before and after liver transplant.
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Bases de dados:
MEDLINE
Assunto principal:
Antivirais
/
Transplante de Fígado
/
Hepacivirus
/
Hepatite C Crônica
/
Doença Hepática Terminal
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Exp Clin Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos