Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis.
Front Neuroendocrinol
; 41: 44-58, 2016 04.
Article
em En
| MEDLINE
| ID: mdl-27234350
ABSTRACT
Psychosocial stress, and within the neuroendocrine reaction to stress specifically the glucocorticoid hormones, are well-characterized inhibitors of neural stem/progenitor cell proliferation in the adult hippocampus, resulting in a marked reduction in the production of new neurons in this brain area relevant for learning and memory. However, the mechanisms by which stress, and particularly glucocorticoids, inhibit neural stem/progenitor cell proliferation remain unclear and under debate. Here we review the literature on the topic and discuss the evidence for direct and indirect effects of glucocorticoids on neural stem/progenitor cell proliferation and adult neurogenesis. Further, we discuss the hypothesis that glucocorticoid rhythmicity and oscillations originating from the activity of the hypothalamus-pituitary-adrenal axis, may be crucial for the regulation of neural stem/progenitor cells in the hippocampus, as well as the implications of this hypothesis for pathophysiological conditions in which glucocorticoid oscillations are affected.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
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Ritmo Circadiano
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Neurogênese
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Células-Tronco Neurais
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Ritmo Ultradiano
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Glucocorticoides
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Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Front Neuroendocrinol
Ano de publicação:
2016
Tipo de documento:
Article