Restrictive Lung Function Is Related to Sympathetic Hyperactivity in Patients With Heart Failure.
J Card Fail
; 23(2): 96-103, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27288844
ABSTRACT
BACKGROUND:
Sympathoexcitation and impaired lung function are common in patients with severe heart failure (HF). However, the association between impaired lung function and sympathoexcitation remains unknown. METHODS ANDRESULTS:
Muscle sympathetic nerve activity (MSNA) and clinical variables were determined in 83 HF patients with left ventricular ejection fraction (LVEF) <0.45. Restrictive and obstructive changes on spirometry were defined as reduced forced vital capacity (FVC) of <80% of predicted and a ratio of forced expiratory volume in the first second to FVC of <70%, respectively. Restrictive and obstructive changes were identified in 17 and 21 patients, respectively. MSNA was higher in patients with restrictive changes than in those without restrictive changes (84 vs 66 bursts per 100 beats; P < .01), but was similar in those with and without obstructive changes. Univariate analyses showed that FVC, estimated glomerular filtration rate (eGFR), specific activity scale, B-type natriuretic peptide level, LVEF, age, and use of aldosterone receptor blockers were significant predictors of MSNA burst incidence. Multivariate analysis revealed that FVC, LVEF, and eGFR were independent factors for increased burst incidence. Changes in FVC during follow-up negatively correlated with changes in burst rate (n = 11; P < .01).CONCLUSION:
Restrictive lung function was associated with increased sympathetic nerve activity independently from HF severity.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Volume Sistólico
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Sistema Nervoso Simpático
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Resistência Vascular
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Insuficiência Cardíaca
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Pneumopatias
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Card Fail
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article