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[Preliminary Clinical Efficiency of Autologous Peripheral Blood Mononuclear Cells for Treating Critical Limb Ischemia of Thromboangiitis Obliterans].
Yu, Jing-Yi; Li, Shang-Zhu; Wu, Li-Hua; Li, Hong-Min; Gao, Wen-Hui; Zheng, Ya-Li; Xu, Ning; Liu, Qing-Guo; Li, Jun-Fan; Liu, Chun-Hua; Hu, Yi-Min; Huang, Ping-Ping.
Afiliação
  • Yu JY; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Li SZ; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Wu LH; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Li HM; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Gao WH; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Zheng YL; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Xu N; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Liu QG; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Li JF; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Liu CH; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Hu YM; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
  • Huang PP; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. E-mail: huangpp66@aliyun.com.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 24(3): 892-6, 2016 Jun.
Article em Zh | MEDLINE | ID: mdl-27342528
ABSTRACT

OBJECTIVE:

To evaluate the long-term clinical effect of autologous peripheral blood mononuclear cells (PB-MNC) on critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) patients.

METHODS:

The clinical data of 22 patients with CLI caused by TAO from July 2004 to May 2013 were analyzed retrospectively, 22 patients were divided into 2 groups; out of them 12 cases in one group were treated with granulocyte colony-stimulating factor (G-CSF)-mobilized autologous peripheral blood mononuclear cells (auto-PBMNC group), 10 cases in another group received conservative treatment (CT group). The log-rank test was used to compare the long-term outcomes in auto-PBMNC group and CT group.

RESULTS:

The wound healing rate (P=0.016) and CLI-free rate (P=0.013) were significantly higher in PB-MNC group compared with that in CT group. No difference was found in amputation rates between the 2 groups (major amputation P=0.361, minor and major amputation P=0.867). No patients died or no serious adverse events occurred during the follow-up period.

CONCLUSION:

The auto-PBMNC therapy can significantly promote the wound healing, and protect against CLI in TAO patients, but the risk of amputation is not low in comparison with conservative treatment.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tromboangiite Obliterante / Leucócitos Mononucleares / Isquemia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Assunto da revista: HEMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tromboangiite Obliterante / Leucócitos Mononucleares / Isquemia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Assunto da revista: HEMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China