Early docosahexaenoic and arachidonic acid supplementation in extremely-low-birth-weight infants.
Pediatr Res
; 80(4): 505-10, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27356083
ABSTRACT
BACKGROUND:
Extremely-low-birth-weight (ELBW) infants accrue large deficits in docosahexaenoic acid (DHA) and arachidonic acid (ARA) and require improved supplementation strategies. We hypothesized that once daily DHA+ARA drops applied to buccal mucosa will increase blood levels.METHODS:
Thirty ELBW infants were randomized to receive DHA 20 mg/kg/d + ARA 40 or 60 mg/kg/d + ARA 120 mg/kg/d or placebo within 72 h of age for 8 wk duration. Red blood cell phospholipid levels of DHA (primary) and ARA (secondary) were measured at 2 and 8 wk of age.RESULTS:
Twenty-eight survivors with a median birth weight of 806 g completed dosing and sampling. Red blood cell levels were similar between the three groups at 2 wk (DHA 4.62 wt% (interquartile range (IQR) 4.1-5.5) for all, P = 0.29 between groups; ARA 21.1 wt% (IQR 18.78-22.6) for all, P = 0.41 between groups) and 8 wk (DHA 6.0 wt% (IQR 5.1-7.1) for all, P = 0.57 between groups; ARA 20.1 wt% (IQR 18.3-23.1) for all, P = 0.63 between groups). DHA in all infants showed a median increase of 31% from 2 to 8 wk (P < 0.04). ARA levels did not significantly change over time (P > 0.6).CONCLUSION:
Daily buccal DHA and ARA supplements did not affect fatty acid levels in ELBW infants.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
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Ácidos Docosa-Hexaenoicos
/
Ácido Araquidônico
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Suplementos Nutricionais
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Recém-Nascido de Peso Extremamente Baixo ao Nascer
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Female
/
Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
Pediatr Res
Ano de publicação:
2016
Tipo de documento:
Article