Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis.
Mech Ageing Dev
; 157: 17-29, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27393639
ABSTRACT
Nonalcoholic steatohepatitis (NASH) is considered to be a common health problem since the incidence of nonalcoholic fatty liver disease (NAFLD) has increased in recent years. Disturbed hepatic cholesterol homeostasis and free cholesterol accumulation in liver results in increased oxidative stress leading to the endoplasmic reticulum (ER) stress. Activated ER stress maintains protein homeostasis however, delayed or inadequate ER stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of NASH. In aging research, there is a growing interest for the role of ER stress in the progression of NASH since aging seems to favor NAFLD according to its pathogenesis. On the other hand, specific microRNAs (miRNAs) expression profiles are strongly related with ER stress as well as NASH progresses. This review highlights molecular mechanisms related to ER stress in the pathogenesis of NASH and miRNAs for the progression and treatment of the disease.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Autofagia
/
Resistência à Insulina
/
Colesterol
/
Apoptose
/
Estresse do Retículo Endoplasmático
/
Hepatopatia Gordurosa não Alcoólica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Turquia