ß-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS).
J Clin Pathol
; 69(9): 826-33, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-27406052
ABSTRACT
AIM:
To evaluate possible colon involvement in the 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS) gastrointestinal polyposis syndrome.METHODS:
Prospective clinicopathological evaluation of two GAPPS families and expression of nuclear ß-catenin, p53 and Ki67 measured by immunohistochemistry on endoscopic and surgical specimens from patients with GAPPS.RESULTS:
Patients with the GAPPS phenotype were more frequently affected by colonic polyps than patients at risk within the same families (p<0.01). Colonic polyps shared immunohistochemical features of fundic gland polyps and gastric cancers including increased expression of nuclear ß-catenin, Ki67 and p53. Both gastric and colonic lesions harboured activating somatic variants of ß-catenin signalling.CONCLUSIONS:
Similarities in expression markers in fundic gland and colonic polyps, together with an enrichment of colonic adenomas in family members affected by GAPPS phenotype compared with family members at risk, support mild colonic involvement of this rare cancer syndrome. Colonoscopic screening might be warranted. CLINICAL TRIAL REGISTRATION NUMBER #09-C-0079; Results.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Adenocarcinoma
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Pólipos do Colo
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Pólipos Adenomatosos
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Beta Catenina
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Clin Pathol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos